Generic Harvoni (Ledipasvir / Sofosbuvir) is an antiviral medication used to treat hepatitis C (Hep C). Generic Harvoni is a combination of ledipasvir and sofosbuvir. It is approved for people with genotype 1 hepatitis C virus. Harvoni is a prescription medication used to treat chronic hepatitis C virus (HCV) infection. It is a combination of two drugs: ledipasvir and sofosbuvir, both of which are direct-acting antiviral agents (DAAs). Harvoni works by targeting specific proteins in the HCV replication process, ultimately stopping the virus from replicating and causing further damage to the liver.