I started taking LDN about 2 months ago, 3 mg daily, and have had quite a struggle with it. I have Hashimoto's, fibromyalgia/CFS, unexplained foot pain, Lyme, IBS, possible SIBO, insomnia and who knows what else. The LDN has helped the pain in my feet somewhat, makes my quality of life more livable. I did suffer with headaches and nausea for about 3 weeks, and then severe constipation for almost 2 mos. but I seem to be passing that phase. I went off for 5 days to get the constipation factor figured out and by the 5th day, I vowed I would get back on and never go off again. I reverted into sick mode and couldn't believe the difference in how I felt. I went back to a lower dose, 1.5 which did nothing for me and quickly got back to 3 mg and plan to go up from here, but slowly. It makes me feel more normal and my elbow tendonitis is not as bad. My sleep is better tho still not that great and I still have some foot pain but for 4 years I walked around with serious pain.