Welcome to the first edition of the Tumor Immunology Round Table
In this edition I present you an very interesting and novel finding
recently published in Journal
of Experimental Medicine by Maness et al: the immune system
induces the mutation by the SIV of an DRIP (defective ribosomal
product) that is immunogenic and induces strong dominant responses in
monkeys infected with SIV. The DRIP derives from a alternative reading
frame of the gene env.
The mutation specifically target the immunogenic peptide presented my
the rhesus macaques haplotype mamu-B*17, as it doesn't affect the env
sequence (sinonimous mutation). The mutation renders the peptide with
much lower affinity than the wild type peptide and therefore the virus
escape the immunological control.
That's a great example of immunological editing of virus and the
conclusions can be easily extrapolated to cancer immune editing.