In this edition of the podcast I will discuss a paper published by
Stemberger and collaborators in the journal Immunity called "A
single naive CD8+ T cells precursor can develop into diverse effector
and memory subset" vol 27, pag 987 of December 2007.
In this very interesting paper the authors redraw the concepts of
memory T cells differentiation from naive T cells, developping a
successfull model of transfer of an single naive T cell precursor. The
paper shows that this single antigen specific naive T cell precursor
can give rise to an diversified memory T cell responses including all
subsets (central memory (CD62L positive, CD127 posit) and effector
memory (CD62L negative, CD127 positive) T cells) upon antigen challenge.
Importantly the kind of memory responses were equivalent in frequency
to the ones generated by the host mice (containing a normal size naive
pool of antigen specific T cells) against an antigenic protein.
See you next time.
PS: The audio has "clicks" arti