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  • 2 years ago
MMP013: Redetermining the ratio of microbial to human cells – correcting the widely held view that t

MMP013: Redetermining the ratio of microbial to human cells – correcting the widely held view that t

Host: Jeff Fox with special guests, Ron Milo and Shai Fuchs. Ron Milo of Weizmann Institute of Science in Rehovot, Israel, and Shai Fuchs at the Hospital for Sick Children in Toronto, Canada, talk with Jeff Fox about their efforts, with Ron Sender at Weizmann, to redetermine the ratio of microbial to human cells. This ratio, widely cited as being 10 to 1, is closer to even, they find, while arguing that it may prove helpful in the long run to have a better and more rigorous grasp of how many cells there are in both the host and the microbiome. Milo, Fuchs, and Sender update the widely-cited 10:1 ratio, “showing that the number of bacteria in our bodies” is instead “of the same order as the number of human cells. Indeed, the numbers are similar enough that each defecation event may flip the ratio to favor human cells over bacteria.” Thus, the total number of bacteria in the ″reference man″ is about 3.9 x 1013 with an uncertainty of 25%, and a variation over the population of 52%. For hu

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